The research in Strisovsky lab is focused on biological membranes and enzymatic catalysis occurring in their context. We are studying intramembrane proteases of the rhomboid family and the mechanistic aspects of their functions relevant for biological signaling, membrane protein biogenesis and homeostasis. In our work we integrate the tools of membrane biochemistry, enzymology and structural biology to understand how rhomboids recognise and select substrates, and employ methods of quantitative proteomics, cell biology and genetics to uncover molecular basis of rhomboid functions in organisms. We are an international group, and we are always looking for motivated and talented students and postdocs who would like to join us. We are located in newly refurbished labs at the Institute of Organic Chemistry and Biochemistry of the Academy of Sciences of the Czech Republic in Prague. Please find out more by following the links on our website.