new paper from the group online
on iRhom in eLife in collaboration with the Adrain lab
Two back to back papers in eLife, by the Adrain and Freeman labs just came online, showing that the stability of the ADAM17/iRhom complex at the plasma membrane is promoted by the FRMD8/iTAP protein that interacts with the cytosolic N-terminus of iRhom. FRMD8/iTAP somehow protects the ADAM17/iRhom complex from being degraded in lysosomes, thereby promoting inflammatory signalling.
Oikonomidi I, Burbridge E, Cavadas M, Sullivan G, Collis B, Naegele H, Clancy D, Brezinova J, Hu T, Bileck A, Gerner C, Bolado A, von Kriegsheim A, Martin SJ, Steinberg F, Strisovsky K, (2018)
iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.
eLife 7: e35032